Name: ANLN 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：ANLN 抗原（重組蛋白）

英文名稱： ANLN Antigen (Recombinant Protein)

別名： anillin, actin binding protein; scra; Scraps

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from C terminal 300 amino acids of human ANLN

技術(shù)規(guī)格：

Full name:	anillin, actin binding protein
Synonyms:	scra; Scraps
Swissprot:	Q9NQW6
Gene Accession:	BC034692
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	?Anillin, also known as scraps homolog, is an evolutionarily conserved Actin- binding protein required for cytokinesis that was first identified in Drosophila melanogaster. Anillin is a ubiquitously expressed protein with highest expression levels in the central nervous system. It is predominantly found in the nucleus and it localizes to the cleavage furrow during cytokinesis, forming a ring with the help of Rac GTPase. During cytokinesis, Anillin interacts with CD2AP and functions to concentrate Rho A and maintain the localization of active Myosin. In Anillin knockout cells the cleavage furrow fails to complete ingression. Anillin expression levels fluctuate with the cell cycle, peaking in mitosis.

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