Name: APEH 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)：APEH 抗原（重組蛋白）

英文名稱(chēng)： APEH Antigen (Recombinant Protein)

別名： acylaminoacyl-peptide hydrolase; APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概述：

Fusion protein corresponding to a region derived from 433-732 amino acids of human APEH

技術(shù)規(guī)格：

Full name:	acylaminoacyl-peptide hydrolase
Synonyms:	APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2
Swissprot:	P13798
Gene Accession:	BC000362
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.

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