Name: CASP1 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： CASP1 抗原（重組蛋白）

英文名稱： CASP1 Antigen (Recombinant Protein)

別名： caspase 1, apoptosis-related cysteine peptidase; ICE, P45, IL1BC

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Full length fusion protein

技術(shù)規(guī)格

Full name:	caspase 1, apoptosis-related cysteine peptidase
Synonyms:	ICE, P45, IL1BC
Swissprot:	P29466
Gene Accession:	BC062327
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

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