Name: CCND1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： CCND1抗原（重組蛋白）

英文名稱(chēng)： CCND1 Antigen (Recombinant Protein)

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別：抗原

概述

Full length fusion protein

技術(shù)規(guī)格

Full name:	cyclin D1
Synonyms:	BCL1, PRAD1, U21B31, D11S287E
Swissprot:	P24385
Gene Accession:	BC000076
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

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