Name: F13A1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： F13A1抗原（重組蛋白）

英文名稱： F13A1 Antigen (Recombinant Protein)

別名： F13A

儲存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to C terminal 250 amino acids of human F13A1

技術(shù)規(guī)格

Full name:	Coagulation factor XIII, A1 polypeptide
Synonyms:	F13A
Swissprot:	P00488
Gene Accession:	BC027963
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.

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