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    • 品牌 : 通蔚生物
    • 目錄號 : TW17017
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中文名稱： PC抗原（重組蛋白）

英文名稱： PC Antigen (Recombinant Protein)

別      名： PCB

儲      存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述

Fusion protein corresponding to a region derived from 563-832 amino acids of human PC

技術(shù)規(guī)格

Full name:

Pyruvate carboxylase

Synonyms:

PCB

Swissprot:

P11498

Gene Accession:

BC011617

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene.

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