Name: EDN3抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： EDN3抗原（重組蛋白）

英文名稱： EDN3 Antigen (Recombinant Protein)

別名： ET3; ET-3; WS4B; HSCR4; PPET3

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from 118-238 amino acids of human EDN3

技術(shù)規(guī)格：

Full name:	endothelin 3
Synonyms:	ET3; ET-3; WS4B; HSCR4; PPET3
Swissprot:	P14138
Gene Accession:	BC008876
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

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