Name: ELP2抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：ELP2抗原（重組蛋白）

英文名稱： ELP2 Antigen (Recombinant Protein)

別名： StIP; StIP1; SHINC-2; STATIP1

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from C terminal 250 amino acids of human ELP2

技術(shù)規(guī)格：

Full name:	elongator acetyltransferase complex subunit 2
Synonyms:	StIP; StIP1; SHINC-2; STATIP1
Swissprot:	Q6IA86
Gene Accession:	BC032553
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis. Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain . A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions . StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation. Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate.

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