Name: GCK抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： GCK抗原（重組蛋白）

英文名稱(chēng)： GCK Antigen (Recombinant Protein)

別名： GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概述：

Fusion protein corresponding to a region derived from 84-290 amino acids of human GCK

技術(shù)規(guī)格：

Full name:	glucokinase (hexokinase 4)
Synonyms:	GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3
Swissprot:	P35557
Gene Accession:	BC001890
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

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