Name: TSG101 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：TSG101 抗原（重組蛋白）

英文名稱： TSG101 Antigen (Recombinant Protein)

別名： tumor susceptibility 101; TSG10; VPS23

儲存： 冷凍（-20℃）

相關(guān)類別：抗原

概述：

Fusion protein corresponding to a region derived from 2-145 amino acids of human TSG101

技術(shù)規(guī)格：

Full name:	tumor susceptibility 101
Synonyms:	TSG10; VPS23
Swissprot:	Q99816
Gene Accession:	BC002487
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.

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