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  • IL17RC抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW17935
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:90
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中文名稱(chēng):IL17RC抗原(重組蛋白)

英文名稱(chēng): IL17RC Antigen (Recombinant Protein)

儲(chǔ)      存: 冷凍(-20℃)

相關(guān)類(lèi)別: 抗原

概述

Fusion protein corresponding to N terminal 357 amino acids of human IL17RC


技術(shù)規(guī)格

Full name:

Interleukin-17 receptor C

Synonyms:

IL17RL

Swissprot:

Q8NAC3

Gene Accession:

BC006411

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.