Name: IPO4 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： IPO4 抗原（重組蛋白）

英文名稱： IPO4 Antigen (Recombinant Protein)

別名： importin 4; Imp4

儲存： 冷凍（-20℃）

相關類別：抗原

概述

Fusion protein corresponding to C terminal 250amino acids of human IPO4

技術規(guī)格

Full name:	importin 4
Synonyms:	Imp4
Swissprot:	Q8TEX9
Gene Accession:	BC003690
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.

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