Name: NGEF 抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：NGEF 抗原（重組蛋白）

英文名稱： NGEF Antigen (Recombinant Protein)

別名： neuronal guanine nucleotide exchange factor; EPHEXIN; ARHGEF27

儲存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to a region derived from 511-710 amino acids of human NGEF

技術規(guī)格：

Full name:	neuronal guanine nucleotide exchange factor
Synonyms:	EPHEXIN; ARHGEF27
Swissprot:	Q8N5V2
Gene Accession:	BC031573
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

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