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  • ECD 抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW18600
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:90
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中文名稱:ECD 抗原(重組蛋白)

英文名稱: ECD Antigen (Recombinant Protein)

別      名: ecdysoneless cell cycle regulator; GCR2; SGT1; HSGT1

儲      存: 冷凍(-20℃)

相關(guān)類別: 抗原

概      述:

Fusion protein corresponding to a region derived from 445-644 amino acids of human ECD


技術(shù)規(guī)格:

Full name:

ecdysoneless cell cycle regulator

Synonyms:

GCR2; SGT1; HSGT1

Swissprot:

O95905

Gene Accession:

BC000721

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).