購物車
幫助
021-54845833/15800441009
中文名稱： 兔抗MLST8多克隆抗體
英文名稱： Anti-MLST8 rabbit polyclonal antibody
別 名： MTOR associated protein, LST8 homolog; GBL; LST8; POP3; WAT1; GbetaL
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： MLST8
反應(yīng)種屬： Human, Mouse, Rat
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. |
|
Applications: |
ELISA, WB |
|
Name of antibody: |
MLST8 |
|
Immunogen: |
Fusion protein of human MLST8 |
|
Full name: |
MTOR associated protein, LST8 homolog |
|
Synonyms: |
GBL; LST8; POP3; WAT1; GbetaL |
|
SwissProt: |
Q9BVC4 |
|
ELISA Recommended dilution: |
5000-10000 |
|
WB Predicted band size: |
36 kDa |
|
WB Positive control: |
Human liver tissue lysate |
|
WB Recommended dilution: |
500-2000 |
