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中文名稱： NSMCE2抗原（重組蛋白）

英文名稱： NSMCE2 Antigen (Recombinant Protein)

別     名：  NSE2; MMS21; ZMIZ7; C8orf36

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述

Full length fusion protein

技術規(guī)格

Full name:

NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase

Synonyms:

NSE2; MMS21; ZMIZ7; C8orf36

Swissprot:

Q96MF7

Gene Accession:

BC032797

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

NSMCE2 is the E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. NSMCE2 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.



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