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中文名稱： 兔抗NR1I3多克隆抗體
英文名稱： Anti-NR1I3 rabbit polyclonal antibody
別 名： nuclear receptor subfamily 1 group I member 3; CAR; CAR1; MB67
相關(guān)類別： 一抗
儲 存： 冷凍（-20℃）
宿 主： Rabbit
抗 原： NR1I3
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
NR1I3 |
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Immunogen: |
Fusion protein of human NR1I3 |
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Full name: |
nuclear receptor subfamily 1 group I member 3 |
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Synonyms: |
CAR; CAR1; MB67 |
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SwissProt: |
Q14994 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human ovarian cancer and Human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
