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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW21750
    • 應(yīng)用 : 僅供科研使用
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    • 規(guī)格 :100ul/200ul/25ul
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中文名稱(chēng):兔抗GPR18多克隆抗體

英文名稱(chēng): Anti-GPR18 rabbit polyclonal antibody

別      名: G protein-coupled receptor 18

相關(guān)類(lèi)別: 一抗

儲(chǔ)      存: 冷凍(-20℃)

宿      主: Rabbit

抗      原: GPR18

反應(yīng)種屬: Human, Mouse, Rat

標(biāo)  記 物: Unconjugate

克隆類(lèi)型: rabbit polyclonal

技術(shù)規(guī)格

Background:

Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).

Applications:

ELISA, IHC

Name of antibody:

GPR18

Immunogen:

Synthetic peptide of human GPR18

Full name:

G protein-coupled receptor 18

SwissProt:

Q14330

ELISA Recommended dilution:

500-1000

IHC positive control:

Human esophagus cancer

IHC Recommend dilution:

25-50


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