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Background: |
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
TLE1 |
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Immunogen: |
Fusion protein of human TLE1 |
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Full name: |
transducin like enhancer of split 1 |
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Synonyms: |
ESG; ESG1; GRG1 |
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SwissProt: |
Q04724 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human cervical cancer |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
83 kDa |
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WB Positive control: |
Human fetal liver tissue lysate |
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WB Recommended dilution: |
200-1000 |


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