購物車
幫助
021-54845833/15800441009
中文名稱：兔抗CDKN1A多克隆抗體
相關(guān)類別： 一抗
抗 原： CDKN1A
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
CDKN1A |
|
Immunogen: |
Fusion protein of human CDKN1A |
|
Full name: |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
|
Synonyms： |
P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 |
|
SwissProt: |
P38936 |
|
ELISA Recommended dilution: |
2000-5000 |
|
IHC positive control: |
Human esophagus cancer |
|
IHC Recommend dilution: |
25-100 |
