購物車
幫助
021-54845833/15800441009
中文名稱：ABL1抗原（重組蛋白）
英文名稱： ABL1 Antigen (Recombinant Protein)
儲 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概述
|
Fusion protein corresponding to a region derived from C terminal 250 amino acids of human ABL1 |
技術(shù)規(guī)格
|
Full name: |
c-abl oncogene 1, non-receptor tyrosine kinase |
|
Synonyms: |
ABL; JTK7; p150; c-ABL; v-abl; c-ABL1; bcr/abl |
|
Swissprot: |
P00519 |
|
Gene Accession: |
BC117451 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. |
