Name: BLNK抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： BLNK抗原（重組蛋白）

英文名稱： BLNK Antigen (Recombinant Protein)

別名： B-cell linker; bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65

相關(guān)類別： 抗原

儲存： 冷凍（-20℃）

概述

Fusion protein corresponding to a region derived from 257-456 amino acids of human BLNK

技術(shù)規(guī)格

Full name:	B-cell linker
Synonyms:	bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65
Swissprot:	Q8WV28
Gene Accession:	BC018906
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.

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