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    • 品牌 : 通蔚生物
    • 目錄號 : TW16587
    • 應(yīng)用 : 僅供科研使用
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    • 規(guī)格 ：1mg/100ug
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中文名稱： EDARADD抗原（重組蛋白）

英文名稱： EDARADD Antigen (Recombinant Protein)

別     名： ED3; EDA3; ECTD11A; ECTD11B

儲     存： 冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Full length fusion protein

技術(shù)規(guī)格

Full name:

EDAR-associated death domain

Synonyms:

ED3; EDA3; ECTD11A; ECTD11B

Swissprot:

Q8WWZ3

Gene Accession:

BC128082

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.



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