Name: BAP1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：BAP1抗原（重組蛋白）

英文名稱： BAP1 Antigen (Recombinant Protein)

別名： UCHL2; hucep-6; HUCEP-13

儲存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from 366-596 amino acids of human BAP1

技術(shù)規(guī)格：

Full name:	BRCA1 associated protein 1
Synonyms:	UCHL2; hucep-6; HUCEP-13
Swissprot:	Q92560
Gene Accession:	BC001596
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

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