Name: DCTN4抗原（重組蛋白）
Brand: 通蔚生物

中文名稱： DCTN4抗原（重組蛋白）

英文名稱： DCTN4 Antigen (Recombinant Protein)

別名： P62; DYN4

儲存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to C terminal 250 amino acids of human DCTN4

技術(shù)規(guī)格：

Full name:	dynactin 4 (p62)
Synonyms:	P62; DYN4
Swissprot:	Q9UJW0
Gene Accession:	BC026323
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton.

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