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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW17142
    • 應(yīng)用 : 僅供科研使用
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中文名稱： RB1抗原（重組蛋白）

英文名稱： RB1 Antigen (Recombinant Protein)

別       名： RB; pRb; OSRC; pp110; p105-Rb

儲(chǔ)       存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述

Fusion protein corresponding to C terminal 300 amino acids of human RB1

技術(shù)規(guī)格

Full name:

retinoblastoma 1

Synonyms:

RB; pRb; OSRC; pp110; p105-Rb

Swissprot:

P06400

Gene Accession:

BC039060

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma

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