Name: PDHA1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：PDHA1抗原（重組蛋白）

英文名稱： PDHA1 Antigen (Recombinant Protein)

別名： PDHA; PDHAD; PHE1A; PDHCE1A

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述：

Fusion protein corresponding to a region derived from 191-390 amino acids of human PDHA1

技術(shù)規(guī)格：

Full name:	pyruvate dehydrogenase E1 alpha 1 subunit
Synonyms:	PDHA; PDHAD; PHE1A; PDHCE1A
Swissprot:	P08559
Gene Accession:	BC002406
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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