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中文名稱POLD2抗原(重組蛋白)

英文名稱: POLD2 Antigen (Recombinant Protein)

儲      存: 冷凍(-20℃)

相關類別: 抗原

概      述:

Fusion protein corresponding to a region derived from 270-469 amino acids of human POLD2


技術規(guī)格:

Full name:

DNA polymerase delta 2, accessory subunit

Swissprot:

P49005

Gene Accession:

BC000459

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.


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