6080yyy午夜理论av片,黄片aaawww,国产色婷婷激情片,久久午夜国产精品,久久色av网址导航,销魂美女做爰免费视频,日韩黄色三级电影在线观看,在线电影人妻在线观看,日本高清成人片www网站免费,长途公共汽车上的轮杆

歡迎來到上海通蔚！

021-54845833/15800441009

品質保證 · 通蔚試劑

當前位置: 首頁 > 科研產品 > 科研抗體 > 其他抗體 > RPS6KA5抗原（重組蛋白）

產品中心

  • RPS6KA5抗原（重組蛋白）

    規(guī)格：
    數(shù)量：

    購買數(shù)量

    價格：￥
    • 品牌 : 通蔚生物
    • 目錄號 : TW18410
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：90
  • 商品詳情
  • 參考文獻
  • 說明書下載
  • 商品評論0
  • 相關產品

中文名稱：RPS6KA5抗原（重組蛋白）

英文名稱： RPS6KA5 Antigen (Recombinant Protein)

別  名：MSK1; RLPK; MSPK1

儲  存： 冷凍（-20℃）

相關類別： 抗原

概述：

Fusion protein corresponding to a region derived from 349-548 amino acids of human RPS6KA5


技術規(guī)格：

Full name:

ribosomal protein S6 kinase A5

Synonyms:

MSK1; RLPK; MSPK1

Swissprot:

O75582

Gene Accession:

BC017187

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (PubMed:11909979, PubMed:12569367, PubMed:12763138, PubMed:9687510, PubMed:18511904, PubMed:9873047). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin (PubMed:11909979, PubMed:9873047). Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression (PubMed:12628924, PubMed:18511904). In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress (PubMed:12628924). In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential (PubMed:12763138). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (PubMed:12569367). Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (PubMed:15010469). Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN (PubMed:12773393). May also phosphorylate 'Ser-28' of histone H3 (PubMed:12773393). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14) (PubMed:12773393). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines (By similarity). Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors (By similarity). Plays a role in neuronal cell death by mediating the downstream effects of excitotoxic injury (By similarity). Phosphorylates TRIM7 at 'Ser-107' in response to growth factor signaling via the MEK/ERK pathway, thereby stimulating its ubiquitin ligase activity (PubMed:25851810).