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  • MLLT11抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW19296
    • 應(yīng)用 : 僅供科研使用
    • 貨期 : 現(xiàn)貨
    • 規(guī)格 ：1mg/100ug
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中文名稱： MLLT11抗原（重組蛋白）

英文名稱： MLLT11 Antigen (Recombinant Protein)

別     名：  AF1Q

儲(chǔ)     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Full length fusion protein

技術(shù)規(guī)格

Full name:

MLLT11 transcription factor 7 cofactor

Synonyms:

AF1Q

Swissprot:

Q13015

Gene Accession:

BC008445

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested.



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