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    • 品牌 : 通蔚生物
    • 目錄號 : TW6760
    • 應(yīng)用 : 僅供科研使用
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中文名稱： ZNF217 抗原（重組蛋白）

英文名稱： ZNF217 Antigen (Recombinant Protein)

別     名： zinc finger protein 217; ZABC1

儲     存： 冷凍（-20℃）

相關(guān)類別：抗原

概     述

Fusion protein corresponding to N terminal 200 amino acids of human ZNF217

技術(shù)規(guī)格

Full name:

zinc finger protein 217

Synonyms:

ZABC1

Swissprot:

O75362

Gene Accession:

BC113427

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

ZNF217, also known as ZABC1, is a zinc finger protein belonging to the Krüppel C2H2-type zinc-finger protein family. It localizes to the nucleus and may play a role in transcriptional repression of a variety of genes through the recruitment of co-repressor complexes containing proteins such as CtBP, HDAC1 and HDAC2. In addition, ZNF217 participates in cell differentiation and appears to function as an oncogene. Expression of ZNF217 is amplified in various tumors and overexpression of the protein can attenuate apoptotic signals and lead to epithelial cell immortalization.Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.


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