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相關(guān)類別： 一抗
抗 原： HLA-DMB
標(biāo) 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
HLA-DMB |
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Immunogen: |
Synthetic peptide of human HLA-DMB |
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Full name: |
major histocompatibility complex, class II, DM beta |
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Synonyms: |
RING7; D6S221E |
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SwissProt: |
P28068 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human tonsil |
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IHC Recommend dilution: |
25-100 |
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WB Predicted band size: |
29 kDa |
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WB Positive control: |
Raji cell lysate |
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WB Recommended dilution: |
200-1000 |
