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  • ANTXR1抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW9372
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:75
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中文名稱:ANTXR1抗原(重組蛋白)

英文名稱:
ANTXR1 Antigen (Recombinant Protein)

儲(chǔ)  存:
冷凍(-20℃)

相關(guān)類別:抗原


概述

Fusion protein corresponding to a region derived from 1-332 amino acids of human ANTXR1


技術(shù)規(guī)格

Full name:

Anthrax toxin receptor 1

Synonyms:

ATR; TEM8

Swissprot:

Q9H6X2

Gene Accession:

BC012074

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.