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中文名稱：CHAT抗原（重組蛋白）

英文名稱：CHAT Antigen (Recombinant Protein)

儲      存：冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 449-748 amino acids of human CHAT


技術(shù)規(guī)格

Full name:

choline O-acetyltransferase

Synonyms:

CMS6; CMS1A; CMS1A2; CHOACTASE

Swissprot:

P28329

Gene Accession:

BC130617

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform.


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