Name: ORC1抗原（重組蛋白）
Brand: 通蔚生物

中文名稱：ORC1抗原（重組蛋白）

英文名稱： ORC1 Antigen (Recombinant Protein)

別名： origin recognition complex subunit 1; ORC1L; PARC1; HSORC1

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類別：抗原

概述

Fusion protein corresponding to a region derived from 662-861 amino acids of human ORC1

技術(shù)規(guī)格

Full name:	origin recognition complex subunit 1
Synonyms:	ORC1L; PARC1; HSORC1
Swissprot:	Q13415
Gene Accession:	BC011539
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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