Name: SELENOM抗原（重組蛋白）
Brand: 通蔚生物

中文名稱(chēng)： SELENOM抗原（重組蛋白）

英文名稱(chēng)： SELENOM Antigen (Recombinant Protein)

別名： SELM; SEPM

儲(chǔ) 存： 冷凍（-20℃）

相關(guān)類(lèi)別：抗原

概述

Fusion protein corresponding to a region derived from 59-145 amino acids of human SELENOM

技術(shù)規(guī)格

Full name:	selenoprotein M
Synonyms:	SELM; SEPM
Swissprot:	Q8WWX9
Gene Accession:	BC013421
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal.

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