購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱(chēng)：FKBP1A抗原（重組蛋白）
英文名稱(chēng)： FKBP1A Antigen (Recombinant Protein)
別 名： FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類(lèi)別： 抗原
概 述：
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Fusion protein corresponding to a region derived from 2-108 amino acids of human FKBP1A |
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Full name: |
FK506 binding protein 1A |
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Synonyms: |
FKBP1; PKC12; PKCI2; FKBP12; PPIASE; FKBP-12; FKBP-1A |
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Swissprot: |
P62942 |
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Gene Accession: |
BC005147 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. |
